1262785-85-2Relevant academic research and scientific papers
Regioselective Sonogashira cross-coupling reactions of 6-chloro-2,8-diiodo- 9-THP-9H-purine with alkyne derivatives
Ibrahim, Nada,Chevot, Franciane,Legraverend, Michel
supporting information; experimental part, p. 305 - 307 (2011/02/26)
Lithiation of 6-chloro-9-(tetrahydro-2H-pyran-2-yl)-9H-purine with LiTMP, gave access to 6-chloro-2,8-dihalogenated purine derivatives. In particular, the 6-chloro-2,8-diiodopurine derivative is an interesting new intermediate which gave regioselectively various 2-alkynylated compounds or 2,8-dialkynylated purines by using an excess of alkyne.
