1262798-89-9

Basic information

• Product Name: N-(3-((4aS,5R,7aS)-2-amino-3,5-dimethyl-4-oxo-3,4,4a,5,7,7a-hexahydrofuro[3,4-d]pyrimidin-7a-yl)-4-fluorophenyl)-5-(difluoromethyl)pyrazine-2-carboxamide
• Synonyms: N-(3-((4aS,5R,7aS)-2-amino-3,5-dimethyl-4-oxo-3,4,4a,5,7,7a-hexahydrofuro[3,4-d]pyrimidin-7a-yl)-4-fluorophenyl)-5-(difluoromethyl)pyrazine-2-carboxamide
• CAS NO: 1262798-89-9
• Molecular Weight: 448.404
• Mol File: 1262798-89-9.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: N-(3-((4aS,5R,7aS)-2-amino-3,5-dimethyl-4-oxo-3,4,4a,5,7,7a-hexahydrofuro[3,4-d]pyrimidin-7a-yl)-4-fluorophenyl)-5-(difluoromethyl)pyrazine-2-carboxamide(CAS DataBase Reference)
• NIST Chemistry Reference: N-(3-((4aS,5R,7aS)-2-amino-3,5-dimethyl-4-oxo-3,4,4a,5,7,7a-hexahydrofuro[3,4-d]pyrimidin-7a-yl)-4-fluorophenyl)-5-(difluoromethyl)pyrazine-2-carboxamide(1262798-89-9)
• EPA Substance Registry System: N-(3-((4aS,5R,7aS)-2-amino-3,5-dimethyl-4-oxo-3,4,4a,5,7,7a-hexahydrofuro[3,4-d]pyrimidin-7a-yl)-4-fluorophenyl)-5-(difluoromethyl)pyrazine-2-carboxamide(1262798-89-9)

Safety Data

• Hazardous Substances Data: 1262798-89-9(Hazardous Substances Data)

Upstream product

• 1262799-33-6 tert-butyl ((4aS,5R,7aS)-7a-(5-amino-2-fluorophenyl)-3,5-dimethyl-4-oxo-3,4,4a,5,7,7a-hexahydrofuro[3,4-d]pyrimidin-2-yl)(N-tert-butoxycarbonyl)carbamate 
• 1262799-31-4 tert-butyl ((4aS,5R,7aS)-7a-(2-fluoro-5-nitrophenyl)-3,5-dimethyl-4-oxo-3,4,4a,5,7,7a-hexahydrofuro[3,4-d]pyrimidin-2-yl)(N-tert-butoxycarbonyl)carbamate 
• 1262799-29-0 (4aS,5R,7aS)-2-amino-7a-(2-fluoro-5-nitrophenyl)-3,5-dimethyl-4a,5,7,7a-tetrahydrofuro[3,4-d]pyrimidin-4(3H)-one 
• 1262799-28-9 tert-butyl ((4aS,5R,7aS)-7a-(2-fluorophenyl)-3,5-dimethyl-4-oxo-3,4,4a,5,7,7a-hexahydrofuro[3,4-d]pyrimidin-2-yl)carbamate 
• 1262799-25-6 (2R,3S,4S)-methyl 4-amino-4-(2-fluorophenyl)-2-methyltetrahydrofuran-3-carboxylate 
• 1262799-23-4 [(3S,4R,5R)-3-(2-fluoro-phenyl)-4-hydroxymethyl-5-methyl-tetrahydro-furan-3-yl]-carbamic acid tert-butylester 
• 1262799-51-8 [(2R,3R,4S)-4-amino-4-(2-fluoro-phenyl)-2-methyl-tetrahydro-furan-3-yl]-methanol 
• 1174321-09-5 t-butyl 5-difluoromethylpyrazine-2-carboxylate 
• 1174321-08-4 t-butyl 5-formylpyrazine-2-carboxylate 
• 1174321-07-3 t-butyl 5-((E)-2-dimethylamino-vinyl)-pyrazine-2-carboxylate 
• 1174321-06-2 5-(difluoromethyl)pyrazine-2-carboxylic acid 
• 1262799-32-5 tert-butyl ((4aS,5R,7aS)-7a-(5-amino-2-fluorophenyl)-3,5-dimethyl-4-oxo-3,4,4a,5,7,7a-hexahydrofuro[3,4-d]pyrimidin-2-yl)(N-tert-butoxycarbonyl)carbamate 
• 1151655-02-5 t-butyl 5-methylpyrazine-2-carboxylate 
• 5521-55-1 2-methylpyrazin-5-carboxylic acid 

Relevant articles and documents

FUSED AMINODIHYDROPYRIMIDONE DERIVATIVES

A compound represented by the general formula (I) or pharmaceutically acceptable salt thereof or a solvate thereof, wherein Ring A is a C6-14 aryl group or the like, L is -NReCO- or the like (wherein Re is a hydrogen atom or the like), Ring B is a C6-14 aryl group or the like, X is a C1-3 alkylene group or the like, Y is a single bond or the like, Z is a C1-3 alkylene group or the like, R1, R2 and Rx are each independently a hydrogen atom or the like, and R3, R4, R5 and R6 are independently a hydrogen atom, a halogen atom or the like, has an Abeta production inhibitory effect or a BACE1 inhibitory effect and is useful as a prophylactic or therapeutic agent for a neurodegenerative disease caused by Abeta and typified by Alzheimer-type dementia.