1262803-10-0

Basic information

• Product Name: N-(3-((4aR,5S,7aS)-2-amino-5-(fluoromethyl)-4a,5,7,7a-tetrahydro-4H-furo[3,4-d][1,3]oxazin-7a-yl)-4-fluorophenyl)-5-(difluoromethyl)pyrazine-2-carboxamide
• Synonyms: N-(3-((4aR,5S,7aS)-2-amino-5-(fluoromethyl)-4a,5,7,7a-tetrahydro-4H-furo[3,4-d][1,3]oxazin-7a-yl)-4-fluorophenyl)-5-(difluoromethyl)pyrazine-2-carboxamide
• CAS NO: 1262803-10-0
• Molecular Weight: 439.369
• Mol File: 1262803-10-0.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: N-(3-((4aR,5S,7aS)-2-amino-5-(fluoromethyl)-4a,5,7,7a-tetrahydro-4H-furo[3,4-d][1,3]oxazin-7a-yl)-4-fluorophenyl)-5-(difluoromethyl)pyrazine-2-carboxamide(CAS DataBase Reference)
• NIST Chemistry Reference: N-(3-((4aR,5S,7aS)-2-amino-5-(fluoromethyl)-4a,5,7,7a-tetrahydro-4H-furo[3,4-d][1,3]oxazin-7a-yl)-4-fluorophenyl)-5-(difluoromethyl)pyrazine-2-carboxamide(1262803-10-0)
• EPA Substance Registry System: N-(3-((4aR,5S,7aS)-2-amino-5-(fluoromethyl)-4a,5,7,7a-tetrahydro-4H-furo[3,4-d][1,3]oxazin-7a-yl)-4-fluorophenyl)-5-(difluoromethyl)pyrazine-2-carboxamide(1262803-10-0)

Safety Data

• Hazardous Substances Data: 1262803-10-0(Hazardous Substances Data)

Upstream product

• 1262803-53-1 tert-butyl [(4aR,5S,7aS)-5-fluoromethyl-7a-(2-fluoro-5-nitrophenyl)-4a,5,7a-tetrahydro-4H-furo[3,4-d][1,3]oxazin-2-yl]carbamate 
• 1262803-52-0 (4aR,5S,7aS)-5-(fluoromethyl)-7a-(2-fluoro-5-nitrophenyl)-4a,5,7,7a-tetrahydro-4H-furo[3,4-d][1,3]oxazin-2-amine 
• 1262803-51-9 (4aR,5S,7aS)-5-fluoromethyl-7a-(2-fluorophenyl)-4a,5,7,7a-tetrahydro-4H-furo[3,4-d][1,3]oxazin-2-ylamine 
• 1262803-50-8 N-[(4aR,5S,7aS)-5-fluoromethyl-7a-(2-fluorophenyl)-4a,5,7,7a-tetrahydro-4H-furo[3,4-d][1,3]oxazin-2-yl]benzamide 
• 1262803-49-5 N-[(4aR,5S,7aS)-7a-(2-fluorophenyl)-5-hydroxymethyl-4a,5,7,7a-tetrahydro-4H-furo[3,4-d][1,3]oxazin-2-yl]benzamide 
• 1262803-48-4 N-[(4aR,5S,7aS)-7a-(2-fluorophenyl)-5-trityloxy-4a,5,7,7a-tetrahydro-4H-furo[3,4-d][1,3]oxazin-2-yl]benzamide 
• 1174321-94-8 (3aR,4S,6aS)-6a-(2-fluorophenyl)-4-trityloxymethyltetrahydrofuro[3,4-c]isoxazole 
• 1174321-92-6 ((S)-1-trityloxymethylallyloxy)acetaldehyde oxime 
• 1174321-96-0 1-benzoyl-3-[(3S,4R,5S)-3-(2-fluorophenyl)-4-hydroxymethyl-5-trityloxymethyl-tetrahydrofuran-3-yl]thiourea 
• 1174321-95-9 [(2S,3R,4S)-4-amino-4-(2-fluorophenyl)-2-trityloxymethyl-tetrahydrofuran-3-yl]methanol 
• 1174321-93-7 (3aR,4S)-4-((trityloxy)methyl)-3,3a,4,6-tetrahydrofuro[3,4-c]isoxazole 
• 1174321-91-5 ethyl ((S)-1-trityloxymethylallyloxy)acetate 
• 1174321-09-5 t-butyl 5-difluoromethylpyrazine-2-carboxylate 
• 1174321-08-4 t-butyl 5-formylpyrazine-2-carboxylate 

Relevant articles and documents

FUSED AMINODIHYDRO-OXAZINE DERIVATIVES

A compound represented by the general formula (I) or a pharmaceutically acceptable salt thereof or a solvate thereof, wherein Ring A is a C6-14 aryl group or the like, L is -NReCO- or the like (wherein Re is a hydrogen atom or the like), Ring B is a C6-14 aryl group or the like, X is a C1-3 alkylene group or the like, Y is a single bond or the like, Z is a C1-3 alkylene group or the like, R1 and R2 are each independently a hydrogen atom or the like, and R3, R4, R5 and R6 are independently a hydrogen atom, a halogen atom or the like, has an Aβ production inhibitory effect or a BACE1 inhibitory effect and is useful as a prophylactic or therapeutic agent for a neurodegenerative disease caused by Aβ and typified by Alzheimer-type dementia.