1262854-86-3Relevant academic research and scientific papers
Synthesis of dysideaproline e using organocatalysis
Owusu-Ansah, Ernest,Durow, Amanda C.,Harding, John R.,Jordan, Angela C.,O'Connell, Susan J.,Willis, Christine L.
, p. 265 - 272 (2011)
(S)-4,4-Dichloro-3-methylbutanoic acid was prepared in 51% overall yield from commercially available starting materials using an organocatalytic transfer hydrogenation to 4,4-dichloro-3-methylbut-2-enal in the key step. The (S)-dichloro acid was used as an intermediate in the first total synthesis of dysideaproline E and a diastereomer confirming the structure of the natural product.
