126295-91-8Relevant articles and documents
A new approach for the synthesis of (±)-trans-10,11-dihydroxy-5,6,6a,7,8,12b-hexahydrobenzo[a]phenanthrid ine (dihydrexidine)
Negash,Nichols
, p. 6971 - 6972 (1996)
A novel method is reported for the synthesis of (±)-trans-10,11-dihydroxy-5,6,6a,7,8,12b-hexahydrobenzo[a]phenanthrid ine (dihydrexidine, 6b) employing as a key step the cyclization of the acid chloride of 3b, via decarbonylation, to the hexahydrobenzo[a]phenanthridine 4b.
trans-10,11-Dihydroxy-5,6,6a,7,8,12b-hexahydrobenzophenanthridine: A Highly Potent Selective Dopamine D1 Full Agonist
Brewster, William K.,Nichols, David E.,Riggs, Robert M.,Mottola, David M.,Lovenberg, Timothy W.,et al.
, p. 1756 - 1764 (2007/10/02)
trans-10,11-Dihydroxy-5,6,6a,7,8,12b-hexahydrobenzophenanthridine (4a, dihydrexidine) has been found to be a highly potent and selective agonist of the dopamine D1 receptor in rat brain.Dihydrexidine had an EC50 of approximately 7
