1262950-34-4

Upstream product

• 1262428-07-8 2-methoxy-4-(3-methyfuroxan-4-yl)-5-nitrophenoxyacetic acid 
• 1325760-32-4 2-methoxy-4-(3-methyfuroxan-4-yl)-5-nitrophenoxyacetylhydrazin 
• 104-88-1 4-chlorobenzaldehyde 
• 7510-46-5 (E)-2-(2-methoxy-4-(prop-1-enyl)phenoxy)acetic acid 

Relevant academic research and scientific papers

Synthesis and NMR spectroscopic characteristics of a series of hydrazide-hydrazones containing furoxan ring derived from isoeugenoxyacetic acid

A novel hydrazide, 2-methoxy-4-(3-methyfuroxan-4-yl)-5- nitrophenoxyacetylhydrazine, was prepared from isoeugenoxyacetic acid. The hydrazide was condensed with aromatic aldehydes to give a series of 20 hydrazide-hydrazones incorporating the furoxan ring. The structure of obtained compounds was determined by analytical and spectral data. It was demonstrated that the two sets of resonance signals in the 1H-NMR and 13C-NMR spectra of the examined hydrazide-hydrazones are caused by EN-C(O) and ZN-C(O) conformers. The energy barriers for the conformation exchange were determined by 1H-NMR-measurement at various temperatures. Among seven tested hydrazide-hydrazones, four compounds exhibit inhibition activities in vitro on human epidermis carcinoma (KB-cell) with IC50 = 47, 68, 79, and 103 μg/mL.