1262985-41-0Relevant academic research and scientific papers
Enantioselective Copper-Catalyzed Methylboration of Alkenes
Chen, Bin,Cao, Peng,Liao, Yang,Wang, Min,Liao, Jian
supporting information, p. 1346 - 1349 (2018/03/09)
An enantioselective Cu-catalyzed borylative cross-coupling reaction of alkenes, bis(pinacolato)diboron (B2(pin)2), and methyl iodide is reported. Alkenes including styrenes, β-substituted styrenes, and challenging aliphatic olefins were smoothly transferred to the desired methylboration products with excellent diastereoselectivities (dr up to >99:1) and enantioselectivities (er up to 99:1). The utility of this process was demonstrated by the synthesis of naproxen and formal synthesis of two natural products.
NHC-Cu-catalyzed enantioselective hydroboration of acyclic and exocyclic 1,1-disubstituted aryl alkenes
Corberan, Rosa,Mszar, Nicholas W.,Hoveyda, Amir H.
, p. 7079 - 7082 (2011/09/30)
Tough nut to crack: Chiral bidentate N-heterocyclic carbene copper complexes were designed that promote enantioselective hydroborations of one of the most difficult substrate classes: acyclic and exocyclic 1,1-disubstituted alkenes undergo reaction with >98% site selectivity, in up to >98% yield and e.r=96.5:3.5 (see scheme, B2(pin)2 = bis(pinacolato)diboron). Copyright
Highly regio- and enantioselective catalytic asymmetric hydroboration of α-substituted styrenyl derivatives
Mazet, Clement,Gerard, David
supporting information; experimental part, p. 298 - 300 (2011/02/24)
The catalytic asymmetric hydroboration of a variety of 1,1-disubstituted olefins has been achieved with excellent yields, perfect regioselectivity and in some cases, high levels of enantioselectivity using readily accessible iridium catalyst.
