126301-14-2

Upstream product

• 104505-09-1 t-butyl (bornylideneamino)acetate 
• 6626-84-2 dimethyl 2-benzylidenepropanedioate 
• 126301-09-5 (2S,3R)-2-Methoxycarbonyl-3-phenyl-4-[1,7,7-trimethyl-bicyclo[2.2.1]hept-(2E)-ylideneamino]-pentanedioic acid 5-tert-butyl ester 1-methyl ester 
• 110269-68-6 tert-butyl ((1R,4R)-bornylideneamino)acetate 
• 126301-09-5 tert-butyl 1,1-dimethyl (2R,3R)-3-<(1R,4R)-bornylideneamino>-2-phenyl-1,1,3-propanetricarboxylate 

Downstream Products

• 133445-97-3 tert-butyl (2R,3S)-3-phenyl-5-oxopyrrolidine-2-carboxylate 

Relevant academic research and scientific papers

Highly Diasteroselective Michael-Addition of Lithiated Camphor Imines of Glycine Esters to α,β-Unsaturated Esters. Synthesis of Optically Pure 5-Oxo-2,4-pyrrolidinedicarboxylates of Unnatural Stereochemistry

The lithium enolates of camphor imines of glycine esters underwent highly diastereoselective Michael additions to the α,β-unsaturated esters.The tightly chelated structure of the Z,E enolates and the selective approach of the α,β-unsaturated esters to the

Absolutely Diastereoselective Asymmetric Michael Addition of the Camphor Imine of t-Butyl Aminoacetate with 2-Alkylidenemalonates

The lithium enolate generated from t-butyl (bornylideneamino)acetate and butyllithium in the presence of t-butyl alcohol undergoes highly diastereoselective asymmetric Michael addition with a variety of α,β-unsaturated esters to afford the anti derivatives of 3-substituted glutamates with 2R-configuration as major products.Use of 2-alkylidenemalonates as Michael acceptors leads to 100 percent diastereoselective Michael additions.