126312-56-9Relevant academic research and scientific papers
Development of potent μ-opioid receptor ligands using unique tyrosine analogues of endomorphin-2
Li, Tingyou,Fujita, Yoshio,Tsuda, Yuko,Miyazaki, Anna,Ambo, Akihiro,Sasaki, Yusuke,Jinsmaa, Yunden,Bryant, Sharon D.,Lazarus, Lawrence H.,Okada, Yoshio
, p. 586 - 592 (2007/10/03)
Six analogues of tyrosine, which contained alkyl groups at positions 2′, 3′, and 6′, either singly or in combination on the tyramine ring, were investigated for their effect on the opioid activity of [Xaa1]endomorphin-2 (EM-2). The opioid analo
Process for producing 2,6-disubstituted tyrosine
-
, (2008/06/13)
A process for making 2,6-disubstituted tyrosine by the noble metal coupling of a disubstituted aromatic halide or diazonium salt with an amino-protected 2-aminoacrylic acid to form a (Z)-β-(disubstituted phenyl)-α-acylaminoacrylate, and asymmetrically hydrogenating the acrylate to produce the 2,6-disubstituted tyrosine.
