126312-62-7Relevant academic research and scientific papers
A convenient asymmetric synthesis of the unnatural amino acid 2,6-dimethyl-L-tyrosine
Dygos,Yonan,Scaros,Goodmonson,Getman,Periana,Beck
, p. 741 - 743 (1992)
The title compound was prepared in high optical purity by a five-step synthesis from 3,5-dimethylphenol on a kilogram scale. The key steps were a modified palladium-catalyzed coupling of an aryl iodide with methyl 2-acetamidoacrylate and hydrogenation of the resulting sterically hindered dehydroamino acid 4 using [Rh(1,5-COD)(R,R-DIPAMP)]BF4 as catalyst.
