1263176-41-5Relevant academic research and scientific papers
Efficient and suitable preparation of N-sulfonyl-1,2,3,4- tetrahydroisoquinolines and ring analogues using recyclable H6P 2W18O62·24H2O/SiO 2 catalyst
Pasquale, Gustavo,Ruiz, Diego,Autino, Juan,Baronetti, Graciela,Thomas, Horacio,Romanelli, Gustavo
, p. 758 - 763 (2012)
Silica gel-supported H6P2W18O 62·24H2O is an efficient and recyclable catalyst for the synthesis of biologically important molecules. Several substituted N-sulfonyl-1,2,3,4-tetrahydroisoquinolines and ring analogues can be prepared in very good yields and purity by direct reaction of N-aralkylsulfonamides and sym-trioxane by a Pictet-Spengler reaction in the presence of a catalytic amount of silica gel-supported H6P2W18O 62·24H2O. Reactions were performed in a low volume of toluene, at 70 °C and for a short time, typically 15 to 30 min. The title heterocyclic compounds were prepared in very good yields (60%-95%) using the described procedure results in a clean and useful alternative, which has the advantages of a greener methodology with operative simplicity, use of a reusable and non-corrosive solid catalyst, soft reaction conditions, low reaction times, and good yields.
