1263193-07-2Relevant academic research and scientific papers
TRIAZOLO- AND PYRAZOLOQUINAZOLINE DERIVATIVES AS PDE10A ENZYME INHIBITOR
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Page/Page column 72, (2012/02/02)
The invention relates to compounds of the formula (I) and their use as pharmaceutical ingredients, in particular for the treatment of CNS related diseases.
Synthesis and SAR study of new phenylimidazole-pyrazolo[1,5-c]quinazolines as potent phosphodiesterase 10A inhibitors
Asproni, Battistina,Murineddu, Gabriele,Pau, Amedeo,Pinna, Gérard A.,Langg?rd, Morten,Christoffersen, Claus Tornby,Nielsen, Jacob,Kehler, Jan
experimental part, p. 642 - 649 (2011/02/27)
A series of phenylimidazole-pyrazolo[1,5-c]quinazolines 1a-q was designed, synthesized and characterised as a novel class of potent phophodiesterase 10A (PDE10A) inhibitors. In this series, 2,9-dimethyl-5-(2-(1-methyl-4-phenyl-1H- imidazol-2-yl)ethyl)pyrazolo[1,5-c]quinazoline (1q) showed the highest affinity for PDE10A enzyme (IC50 = 16 nM).
