1263284-26-9

Basic information

• Product Name: 1,2,3,4-tetrahydrocyclopenta[b]indol-2-amine
• Synonyms: 1,2,3,4-tetrahydrocyclopenta[b]indol-2-amine
• CAS NO: 1263284-26-9
• Molecular Formula: C11H12N2
• Molecular Weight: 172
• Mol File: 1263284-26-9.mol
• Article Data: 0

Chemical Properties

• Boiling Point: 340.0±42.0 °C(Predicted)
• Appearance: /
• Density: 1.243±0.06 g/cm3(Predicted)
• Storage Temp.: under inert gas (nitrogen or Argon) at 2–8 °C
• PKA: 17.45±0.40(Predicted)
• CAS DataBase Reference: 1,2,3,4-tetrahydrocyclopenta[b]indol-2-amine(CAS DataBase Reference)
• NIST Chemistry Reference: 1,2,3,4-tetrahydrocyclopenta[b]indol-2-amine(1263284-26-9)
• EPA Substance Registry System: 1,2,3,4-tetrahydrocyclopenta[b]indol-2-amine(1263284-26-9)

Safety Data

• Hazardous Substances Data: 1263284-26-9(Hazardous Substances Data)

Usage

Description

1,2,3,4-tetrahydrocyclopenta[b]indol-2-amine, commonly known as tetrahydroharmane, is a naturally occurring indole alkaloid compound. It is found in various plant species, such as Peganum harmala (Syrian Rue) and Banisteriopsis caapi (Ayahuasca). Tetrahydroharmane exhibits psychoactive properties and has been identified as a serotonin and adrenergic receptor agonist, as well as a monoamine oxidase (MAO-A and MAO-B) inhibitor. Its potential as a biomarker for neurological disorders, including Parkinson's disease, is currently under investigation, with ongoing research aimed at elucidating its pharmacological properties and possible therapeutic applications.

Uses

Used in Pharmaceutical Industry:
1,2,3,4-tetrahydrocyclopenta[b]indol-2-amine is used as a psychoactive compound for its ability to modulate serotonin and adrenergic receptors, which may contribute to its potential therapeutic effects in treating certain neurological and psychiatric conditions.
Used in Neurological Research:
1,2,3,4-tetrahydrocyclopenta[b]indol-2-amine is used as a potential biomarker for neurological disorders, such as Parkinson's disease, due to its presence in affected individuals and its possible involvement in disease progression.
Used in Drug Development:
1,2,3,4-tetrahydrocyclopenta[b]indol-2-amine is used as a lead compound in the development of new pharmaceuticals targeting monoamine oxidase enzymes, which play a crucial role in the regulation of neurotransmitter levels in the brain. Its MAO-A and MAO-B inhibitory activity may contribute to the development of treatments for depression, anxiety, and other mood disorders.
Used in Ethnopharmacology:
1,2,3,4-tetrahydrocyclopenta[b]indol-2-amine is used in traditional and indigenous medicine practices, particularly in the context of plant-based shamanic brews, such as Ayahuasca, where it may contribute to the overall psychoactive effects of the concoction.