1263286-84-5Relevant academic research and scientific papers
Synthesis of the spiroketal fragment of bistramide A via an exocyclic enol ether
Tomas, Lo?c,Gueyrard, David,Goekjian, Peter G.
, p. 4599 - 4601 (2010)
An efficient synthesis of the spirocyclic fragment 1 of bistramides is reported. An olefination reaction of lactone 4 with sulfone 5 gave the enol ether 3, which upon cyclization in acidic media provided the spiroketal ring system. This compound was then converted into the C19-C36 fragment of the bistramides via successive Julia-Kocienski and Horner-Emmons olefinations.
