1263313-41-2Relevant academic research and scientific papers
Palladium-catalyzed intermolecular directed C-H amidation of aromatic ketones
Xiao, Bin,Gong, Tian-Jun,Xu, Jun,Liu, Zhao-Jing,Liu, Lei
supporting information; experimental part, p. 1466 - 1474 (2011/04/16)
Pd-catalyzed directed ortho C-H amidation of aromatic ketones with both sulfonamides and amides has been accomplished. The use of an electron-deficient Pd complex, Pd(OTf)2, is crucial for the success of this transformation. Some key intermediates of the reaction, that is, the cyclopalladation complexes of ketones, have been characterized by X-ray crystallography. Experimental analysis of these palladacycles and also the experimental results with N-methyl sulfonamides indicate that the new reaction does not seem to proceed through a nitrene intermediate. The utility of the newly developed reaction was demonstrated for the synthesis of useful organic intermediates such as 2- and 3-alkyl indoles and 2-aminophenyl ketones.
