1263313-62-7

Basic information

• Product Name: 2,2-dimethyl-1-[1-(toluene-4-sulfonyl)-1H-indol-3-yl]-propan-1-one
• Synonyms: 2,2-dimethyl-1-[1-(toluene-4-sulfonyl)-1H-indol-3-yl]-propan-1-one
• CAS NO: 1263313-62-7
• Molecular Weight: 355.458
• Mol File: 1263313-62-7.mol
• Article Data: 2

Chemical Properties

• CAS DataBase Reference: 2,2-dimethyl-1-[1-(toluene-4-sulfonyl)-1H-indol-3-yl]-propan-1-one(CAS DataBase Reference)
• NIST Chemistry Reference: 2,2-dimethyl-1-[1-(toluene-4-sulfonyl)-1H-indol-3-yl]-propan-1-one(1263313-62-7)
• EPA Substance Registry System: 2,2-dimethyl-1-[1-(toluene-4-sulfonyl)-1H-indol-3-yl]-propan-1-one(1263313-62-7)

Safety Data

• Hazardous Substances Data: 1263313-62-7(Hazardous Substances Data)

Upstream product

• 69622-35-1 1-(1H-indol-3-yl)-2,2-dimethylpropan-1-one 
• 98-59-9 p-toluenesulfonyl chloride 

Downstream Products

• 1263313-61-6 4-chloro-N-[3-(2,2-dimethyl-propionyl)-1-(toluene-4-sulfonyl)-1H-indol-4-yl]-benzenesulfonamide 

Relevant articles and documents

Selective C-H acylation of indoles with α-oxocarboxylic acids at the C4 position by palladium catalysis

The first Pd-catalyzed direct C-H acylation of indoles at the C4 position with α-oxocarboxylic acids using a ketone directing group is described. This reaction exhibits high regioselectivity with the tolerance of a wide scope of functional groups to afford diverse acylated indoles in moderate-to-good yields. The control experiments evidence the generation of acyl radicals via K2S2O8 promoted decarboxylation of α-oxocarboxylic acids and the involvement of a PdII/PdIV catalytic cycle. Importantly, the synthetically useful selectivity observed might be applied to prepare indole derivatives with anti-tumor activity as tubulin inhibitors.