1263314-59-5Relevant articles and documents
C-O hydrogenolysis catalyzed by Pd-PMHS nanoparticles in the company of chloroarenes
Rahaim, Ronald J.,Maleczka, Robert E.
, p. 584 - 587 (2011)
Catalytic Pd(OAc)2 and polymethylhydrosiloxane (PMHS), in conjunction with aqueous KF, and a catalytic amount of an aromatic chloride, effects the chemo-, regio-, and stereoselective deoxygenation of benzylic oxygenated substrates at room temperature in THF. Preliminary mechanistic experiments suggest the process to involve palladium-nanoparticle-catalyzed hydrosilylation followed by C-O reduction. The chloroarene additive appears to facilitate the hydrogenolysis process through the slow controlled release of HCl.