126337-06-2

Upstream product

• 33389-38-7 5-chloro-2-methyl-6-phenylpyridazin-3(2H)-one 
• 126337-04-0 5-azido-6-phenyl-3(2H)-pyridazinone 
• 4637-24-5 N,N-dimethyl-formamide dimethyl acetal 
• 71-43-2 benzene 
• 72857-85-3 α,β-dichloro-γ-phenyl-Δ^α,β-crotonolactone 

Downstream Products

• 126336-94-5 5-amino-2-methyl-6-phenylpyridazin-3(2H)-one 
• 126337-09-5 C₂₉H₂₄N₃OP 
• 1610354-59-0 phenyl 1-methyl-6-oxo-3-phenyl-1,6-dihydropyridazin-4-ylcarbamate 
• 1610354-26-1 1-((3S,4R)-4-(3,4-difluorophenyl)-1-(2-methoxyethyl)pyrrolidin-3-yl)-3-(1-methyl-6-oxo-3-phenyl-1,6-dihydropyridazin-4-yl)urea 

Relevant academic research and scientific papers

PYRROLIDINYL UREA, THIOUREA, GUANIDINE AND CYANOGUANIDINE COMPOUNDS AS TRKA KINASE INHIBITORS

Compounds of Formula (I): or stereoisomers, tautomers, or pharmaceutically acceptable salts, or solvates or prodrugs thereof, where R1, R2, Ra, Rb, Rc, Rd, X, Ring B, and Ring C are as defined herein, and wherein Ring B moiety and the NH-C(=X)-NH moiety are in the trans configuration, are inhibitors of TrkA kinase and are useful in the treatment of diseases which can be treated with a TrkA kinase inhibitor such as pain, cancer, inflammation/inflammatory diseases, neurodegenerative diseases, certain infectious diseases, Sjogren's syndrome, endometriosis, diabetic peripheral neuropathy, prostatitis and pelvic pain syndrome.

Pyridazine derivatives. XXIV. Efficient N-methylation of diversely substituted 3(2H)-pyridazinones using N,N-dimethylformamide dimethylacetal

A series of diversely substituted 3(2H)-pyridazinones were efficiently N-methylated at position 2 by treatment with N,N-dimethylformamide dimethylacetal in DMF.

Synthesis of Aminopyridazines from Azidopyridazines and Tetrazolopyridazines

Azidopyridazines 3, 4, 24 and tetrazolopyridazines 10, 13, 28 can be converted to the corresponding aminopyridazines, by reaction with triphenylphosphine via phosphazenes and subsequent hydrolysis (Staudinger reaction).