1263409-66-0Relevant academic research and scientific papers
Hexaphyrin as a Potential Theranostic Dye for Photothermal Therapy and 19F Magnetic Resonance Imaging
Higashino, Tomohiro,Nakatsuji, Hirotaka,Fukuda, Ryosuke,Okamoto, Haruki,Imai, Hirohiko,Matsuda, Tetsuya,Tochio, Hidehito,Shirakawa, Masahiro,Tkachenko, Nikolai V.,Hashida, Mitsuru,Murakami, Tatsuya,Imahori, Hiroshi
, p. 951 - 959 (2017)
Two features of meso-Aryl-substituted expanded porphyrins suggest suitability as theranostic agents. They have excellent absorption in near infrared (NIR) region, and they offer the possibility of introduction of multiple fluorine atoms at structurally equivalent positions. Here, hexaphyrin (hexa) was synthesized from 2,6-bis(trifluoromethyl)-4-formyl benzoate and pyrrole and evaluated as a novel expanded porphyrin with the above features. Under NIR illumination hexa showed intense photothermal and weak photodynamic effects, which were most likely due to its low excited states, close to singlet oxygen. The sustained photothermal effect caused ablation of cancer cells more effectively than the photodynamic effect of indocyanine green (a clinical dye). In addition, hexa showed potential for use in the visualization of tumors by 19F magnetic resonance imaging (MRI), because of the multiple fluorine atoms. Our results strongly support the utility of expanded porphyrins as theranostic agents in both photothermal therapy and 19F MRI.
"Click-made" biaryl-linker improving efficiency in protein labelling for the membrane target protein of a bioactive compound
Nakamura, Yoko,Inomata, Sho,Ebine, Makoto,Manabe, Yoshiyuki,Iwakura, Izumi,Ueda, Minoru
supporting information; experimental part, p. 83 - 85 (2011/02/24)
We report on the design, synthesis and assessment of a novel biaryl-linked (BArL) molecular probe for the exploration of low-abundant target proteins for bioactive compounds based on the activity based protein profiling (ABPP) approach. Surprisingly, the
