1263474-73-2Relevant academic research and scientific papers
Natural feedstocks for diversity-oriented synthesis: Macrolide-like scaffolds from nonactate
Sumskaya, Yuliya G.,Swain, P. Whitney,Bergmeier, Stepehen C.,McMills, Mark C.,Priestley, Nigel D.,Wrighta, Dennis L.
, p. 144 - 166 (2011/07/07)
We have been interested in the application of readily available, fermentation-derived natural products as key building blocks for the preparation of natural product-like libraries rich in structural and stereochemical diversity. In this manuscript we describe the conversion of methyl nonactate, derived from nonactin, to a diversable scaffold characteristic of macrolide natural products. The synthesis features a key ring-closing metathesis reaction to form the macrocycle. ARKAT-USA, Inc.
