1263479-95-3

Basic information

• Product Name: 4-{4-[4-(4-methanesulfonyl-piperidin-1-yl)-indazol-1-yl]-pyrimidin-2-ylamino}-cyclohexanecarboxylic acid ethyl ester
• CAS NO: 1263479-95-3
• Molecular Weight: 526.66
• Mol File: 1263479-95-3.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: 4-{4-[4-(4-methanesulfonyl-piperidin-1-yl)-indazol-1-yl]-pyrimidin-2-ylamino}-cyclohexanecarboxylic acid ethyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: 4-{4-[4-(4-methanesulfonyl-piperidin-1-yl)-indazol-1-yl]-pyrimidin-2-ylamino}-cyclohexanecarboxylic acid ethyl ester(1263479-95-3)
• EPA Substance Registry System: 4-{4-[4-(4-methanesulfonyl-piperidin-1-yl)-indazol-1-yl]-pyrimidin-2-ylamino}-cyclohexanecarboxylic acid ethyl ester(1263479-95-3)

Safety Data

• Hazardous Substances Data: 1263479-95-3(Hazardous Substances Data)

Upstream product

• 1032451-36-7 4-bromo-1-(2-methylsulfanyl-pyrimidin-4-yl)-1H-indazole 
• 1263480-63-2 4-(4-methanesulfonyl-piperidin-1-yl)-1-(2-methylsulfanyl-pyrimidin-4-yl)-1H-indazole 
• 1263480-64-3 C₁₈H₂₁N₅O₄S₂ 
• 1678-68-8 ethyl trans-4-aminocyclohexanecarboxylate 

Relevant articles and documents

Development of indole/indazole-aminopyrimidines as inhibitors of c-Jun N-terminal kinase (JNK): Optimization for JNK potency and physicochemical properties

A novel series of indole/indazole-aminopyrimidines was designed and synthesized with an aim to achieve optimal potency and selectivity for the c-Jun kinase family or JNKs. Structure guided design was used to optimize the series resulting in a significant potency improvement. The best compound (17) has IC50 of 3 nM for JNK1 and 20 nM for JNK2, with greater than 40-fold selectivity against other kinases with good physicochemical and pharmacokinetic properties.