126348-18-3Relevant academic research and scientific papers
Magnetic magnetite nanoparticals catalyzed selective oxidation of Α-hydroxy ketones with air and one-pot synthesis of benzilic acid and phenytoin derivatives
Li, Xiaona,Xia, Dandan,Wen, Zhiyong,Gong, Bowen,Sun, Maolin,Wu, Yue,Zhang, Jie,Sun, Jun,Wu, Yang,Bao, Kai,Zhang, Weige
, p. 63 - 69 (2018/06/26)
A clean and efficient protocol for selective oxidation of α-hydroxy ketones using magnetic magnetite nanoparticals (Fe3O4·MNPs) as catalyst with air as green oxidant has been developed. Application of Fe3O4·MNPs was also proved to be successful in one-pot synthesis of benzilic acid and phenytoin derivatives. The facile one-pot procedure enhanced the production efficiency, shortened the reaction time and minimized the chemical waste. Notably, the catalyst can be reused at least for five times without any appreciable loss of its activity.
Preparation of Some Chromans Substituted at the 3- or 4-Position by an Aryl or Benzyl Group, by the Rhodium-catalysed Intramolecular Nucleophilic Substitution of the Corresponding 3-(2-Fluorophenyl)propanols
Houghton, Roy P.,Shervington, Leroy A.
, p. 1872 - 1892 (2007/10/02)
The bis(hexafluorophosphate) salt of the (η5-ethyltetramethylcyclopentadienyl)(η6-benzene)rhodium(III) cation has been used as a catalyst to prepare 3-phenyl-, 3-(4-methoxyphenyl)-, 3-(4-nitrophenyl)-, and 4-benzylchroman by cyclisation of the corresponding substituted 3-(2-fluorophenyl)-propanols in nitromethane-acetone solution. 3-Phenyl-4-hydroxymethylchroman and 3-hydroxymethyl-4-phenylchroman were prepared similarly.An attempt to prepare a bis(chroman) by a double cyclisation with 2-propane-1,3-diol afforded only the monochroman, 4-(2-fluorophenyl)-3-hydroxymethylchroman.Under the conditions of the cyclisation, the erythro and threo forms of 1,4-di(2-fluorophenyl)-butane-2,3-diol afforded only the corresponding 1,3-dioxolanes as the result of the diols reacting with the acetone used as cosolvent.The 1H n.m.r. spectra of the 3-substituted and 3,4-disubstituted chromans which have been prepared are consistent with the heterocyclic ring being in the half-chair conformation (6).
