1263483-49-3Relevant academic research and scientific papers
Preparation method of fluralaner intermediate
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Paragraph 0031-0033; 0036-0038, (2021/03/30)
The invention relates to a preparation method of a fluralaner intermediate, which comprises the following steps of: carrying out addition reaction on 4-cyano-2-methyl toluate serving as an initial reactant and hydroxylamine to obtain 4-formamide oxime-2-methyl toluate, carrying out diazotization and denitrification reaction in sequence to obtain a halogen oxime compound, and finally carrying out addition cyclization reaction on the halogen oxime compound and 1, 3-dichloro-5-(1-trifluoromethyl-vinyl) benzene to obtain a target product fluralaner intermediate. Amidoxime is prepared through an addition reaction, and then halogenated oxime is prepared through a diazotization reaction. Compared with reduction, oximation and chlorination reactions in the prior art, the preparation process is greatly simplified, the process conditions are mild, safe and environmentally friendly, the yield can reach 70% or above, and the method is suitable for industrial production.
AMIDE DERIVATIVE
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Page/Page column 12, (2012/06/01)
Provided are a compound having an excellent hypoglycemic action, or a pharmaceutically acceptable salt thereof, and a pharmaceutical composition having an excellent therapeutic effect and/or prophylactic effect on type 1 diabetes, type 2 diabetes, and the like, which cause an increase in the blood sugar level due to abnormal sugar metabolism. A compound represented by general formula (I), or a pharmaceutically acceptable salt thereof, is disclosed.
