1263499-38-2Relevant academic research and scientific papers
N -Protecting group tuning of the enantioselectivity in Strecker reactions of trifluoromethyl ketimines to synthesize quaternary α-trifluoromethyl amino nitriles by ion pair catalysis
Du, Mengyuan,Yu, Longhui,Du, Ting,Li, Zhaokun,Luo, Yueyang,Meng, Xiangyu,Tian, Zhengtao,Zheng, Changwu,Cao, Weiguo,Zhao, Gang
supporting information, p. 1581 - 1584 (2020/02/13)
An enantioselective Strecker reaction to construct trifluoromethylated quaternary stereocenters with N-PMP and unexplored N-Boc trifluoromethyl ketimines catalyzed using an organophosphine dual-reagent catalyst has been developed. The enantioselectivities
Organocatalytic enantioselective strecker synthesis of α-quaternary α-trifluoromethyl amino acids
Enders, Dieter,Gottfried, Katharina,Raabe, Gerhard
supporting information; experimental part, p. 3147 - 3152 (2011/02/22)
The first organocatalytic enantioselective Strecker synthesis of α-quaternary α-trifluoromethylated amino acids has been developed. Employing Takemoto's thiourea catalyst the nucleophilic addition of trimethylsilyl cyanide to trifluoromethyl ketimines aff
