1263501-10-5Relevant academic research and scientific papers
1,2-disubstituted hexahydro-1 H -benzo[d]imidazoles: Synthesis, characterization, and stability
Tydlitat, Jiri,Bures, Filip,Kulhanek, Jiri,Ruzicka, Ales
, p. 3934 - 3940 (2010)
Starting from commercially available (hetero)aromatic nitriles and (1R,2R)-cyclohexane-1,2-diamine, nine NH-imidazolines (hexahydro-1H-benzo[d] imidazoles) were synthesized in good yields. The molecular structures of three imidazolines were confirmed by X-ray analysis. N-Benzylation afforded some of the desired N-benzylimidazolines, but was incompatible with imidazolines that possessed strong electron-accepting heteroaromatic groups at C2. In the latter cases, the products decomposed during column chromatography to form N,N-disubstituted cyclohexane-1,2-diamines. Georg Thieme Verlag Stuttgart · New York.
