1263764-80-2Relevant academic research and scientific papers
Synthesis and anticonvulsant activity of some alkanamide derivatives
Tarikogullari, Ayse H.,Kilic, Fatma Sultan,Erol, Kevser,Pabuccuoglu, Varol
experimental part, p. 593 - 598 (2011/05/19)
A group of N -phenylacetamide, N-phenylpropanamide and N-benzylamide derivatives bearing 5-membered heterocyclic rings such as pyrazole, 1,2,4-triazole and imidazole rings at ω position were synthesized and their anticonvulsant activity was evaluated in the maximal electroshock test. The results indicated that the 1,2,4-triazole ring leads to superior activity than the pyrazole ring and inserting a CH2 group into the anilide structure leading to N-benzyl derivatives did not change the anticonvulsant activity, but caused a noticeable decrease in duration of action. The most active compound was 2-(1H-1,2,4-triazole-1-yl)-N-(2,6-dimethylphenyl)acetamide. ECV · Editio Cantor Verlag.
