1263776-45-9

Basic information

• Product Name: N-[5-(ethylsulfanyl)-1,3,4-thiadiazole-2-yI]-5-methoxy-1-H-indole-2-carboxamide
• CAS NO: 1263776-45-9
• Molecular Weight: 334.423
• Mol File: 1263776-45-9.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: N-[5-(ethylsulfanyl)-1,3,4-thiadiazole-2-yI]-5-methoxy-1-H-indole-2-carboxamide(CAS DataBase Reference)
• NIST Chemistry Reference: N-[5-(ethylsulfanyl)-1,3,4-thiadiazole-2-yI]-5-methoxy-1-H-indole-2-carboxamide(1263776-45-9)
• EPA Substance Registry System: N-[5-(ethylsulfanyl)-1,3,4-thiadiazole-2-yI]-5-methoxy-1-H-indole-2-carboxamide(1263776-45-9)

Safety Data

• Hazardous Substances Data: 1263776-45-9(Hazardous Substances Data)

Upstream product

• 25660-70-2 2-amino-5-(ethylthio)-1,3,4-thiadiazole 
• 4382-54-1 5-methoxy-1H-indole-2-carboxylic acid 

Relevant articles and documents

Synthesis, testing and structure-activity studies on a library of 5-HT 4 ligands

Several indole derivatives and analogues comprising a range of related structural classes were designed, synthesized and tested as ligands for the 5-HT4 receptor. Within each series, binding experiments showed compounds with good affinity demonstrating high percentage displacement values at 1 μM. The most potent of these (20) had a pKi of 8.54 demonstrating very good affinity. These indole analogues were combined with 55 ligands that were previously produced in our laboratory to explore the structure-activity relationships of these 5-HT4 ligands. A CoMFA (Comparative Molecular Field Analysis) analysis was used to extend an earlier simple pharmacophore to suggest two new molecular features beyond the primary amino binding site. The pharmacophore confirmed that a newly described tetrahydroquinoline analogue was able to match the basic requirements of the model and the pharmacology of this molecule is provided in more detail.