1264-62-6

Basic information

• Product Name: Erythromycin ethylsuccinate
• Synonyms: ERYTHROMYCIN 2'-(ETHYL BUTANEDIOATE);ERYTHROMYCIN 2'-(ETHYL SUCCINATE);ERYTHROMYCIN ETHYLSUCCINATE;erythrocinethylsuccinate;erythromycin,mono(ethylsuccinate);erythromycin,mono(ethylsuccinate)(ester);Succinic acid, monoester with erythromycin;Erythromycin 2''-[3-(ethoxycarbonyl)propionate]
• CAS NO: 1264-62-6
• Molecular Formula: C₄₃H₇₅NO₁₆
• Molecular Weight: 862.05
• EINECS: 215-033-8
• Product Categories: ERYPED;Organics;Interferes with Protein SynthesisAntibiotics;A - KAntibiotics;Antibacterial;Antibiotics A to;Antibiotics A-FAntibiotics;Chemical Structure Class;Macrolides;Mechanism of Action;Spectrum of Activity
• Mol File: 1264-62-6.mol
• Article Data: 0

Chemical Properties

• Melting Point: 219-224 C
• Boiling Point: 778.19°C (rough estimate)
• Flash Point: >110°(230°F)
• Appearance: white/
• Density: 1.1417 (rough estimate)
• Vapor Pressure: 4.94E-31mmHg at 25°C
• Refractive Index: 1.5280 (estimate)
• Storage Temp.: 2-8°C
• Solubility: ethanol: soluble50mg/mL
• PKA: 13.09±0.70(Predicted)
• Water Solubility: Freely soluble in organic solvents, practically insoluble in water
• Stability: Hygroscopic
• CAS DataBase Reference: Erythromycin ethylsuccinate(CAS DataBase Reference)
• NIST Chemistry Reference: Erythromycin ethylsuccinate(1264-62-6)
• EPA Substance Registry System: Erythromycin ethylsuccinate(1264-62-6)

Safety Data

• Hazard Codes: Xn,Xi
• Statements: 42/43-36/37/38
• Safety Statements: 36-26
• WGK Germany: 2
• RTECS: WM9800000
• Hazardous Substances Data: 1264-62-6(Hazardous Substances Data)

Usage

Chemical Properties

ERYTHROMYCIN ETHYLSUCCINATE is crystals

Uses

Different sources of media describe the Uses of 1264-62-6 differently. You can refer to the following data:
1. antibacterial
2. A broad spectrum antibiotic commonly targeting bacteria responsible for respiratory tract infections

Brand name

E-Mycin (Pharmacia & Upjohn); E.E.S. (Abbott); Eryped (Abbott); Pediamycin (Ross); Wyamycin (Wyeth).

General Description

Erythromycin ethylsuccinate (EES, Pediamycin, EryPed) isthe ethylsuccinate mixed ester of erythromycin in which the2＇-hydroxyl group of the desosamine is esterified. It isabsorbed as the ester and hydrolyzed slowly in the body toform erythromycin. It is somewhat acid labile, and itsabsorption is enhanced by the presence of food. The ester isinsoluble in water but soluble in alcohol and ether.

InChI:InChI=1/C37H67NO13.C6H10O4/c1-14-25-37(10,45)30(41)20(4)27(39)18(2)16-35(8,44)32(51-34-28(40)24(38(11)12)15-19(3)47-34)21(5)29(22(6)33(43)49-25)50-26-17-36(9,46-13)31(42)23(7)48-26;1-2-10-6(9)4-3-5(7)8/h18-26,28-32,34,40-42,44-45H,14-17H2,1-13H3;2-4H2,1H3,(H,7,8)/p-1/t18-,19-,20+,21+,22-,23+,24+,25-,26+,28-,29+,30-,31+,32-,34+,35-,36-,37-;/m1./s1

Upstream product

• 14794-31-1 ethyl 3-(chloroformyl)propionate 
• 114-07-8 erythromycin 

Related news

Determination of Erythromycin ethylsuccinate (cas 1264-62-6) by liquid chromatography08/14/2019

A method is described for the determination of erythromycin ethylsuccinate by liquid chromatography. A C18 reversed-phase column (25 cm x 4.6 mm I.D.) was used with acetonitrile-0.2 M tetrabutylammonium sulphate (pH 6.5)-0.2 M phosphate buffer (pH 6.5)-water [x:5:5:(90 - x)] as mobile phase. The...detailed

Construction of universal quantitative models for determination of roxithromycin and Erythromycin ethylsuccinate (cas 1264-62-6) in tablets from different manufacturers using near infrared reflectance spectroscopy08/13/2019

Universal quantitative models using NIR reflectance spectroscopy were developed for the analysis of API contents (active pharmaceutical ingredient) in roxithromycin and erythromycin ethylsuccinate tablets from different manufacturers in China. The two quantitative models were built from 78 batch...detailed

Simultaneous determination of Erythromycin ethylsuccinate (cas 1264-62-6) and its metabolite erythromycin in human plasma using liquid chromatography–electrospray ionization mass spectrometry for clinical study08/12/2019

A sensitive and selective liquid chromatography–electrospray ionization mass spectrometry (LC–ESI-MS) method was developed for simultaneous identification and quantification of erythromycin ethylsuccinate and erythromycin in human plasma, which can be well applied to clinical study. The method...detailed

Voltammetric behavior of Erythromycin ethylsuccinate (cas 1264-62-6) at a renewable silver-amalgam film electrode and its determination in urine and in a pharmaceutical preparation08/11/2019

Erythromycin, a macrolide antibiotic, has similar antimicrobial spectrum to penicillin and it is widely used, especially in the treatment of patients who are allergic to penicillin.In this work, the application of a renewable silver-amalgam film electrode (Hg(Ag)FE) for the characterization and ...detailed

Development of a stability-indicating high performance liquid chromatography method for assay of Erythromycin ethylsuccinate (cas 1264-62-6) in powder for oral suspension dosage form08/10/2019

In this study an effective method was developed to assay erythromycin ethylsuccinate for an oral suspension dosage form. The chromatographic separation was achieved on an X-Terra™ C18 analytical column. A mixture of acetonitrile–ammonium dihydrogen phosphate buffer (0.025 mol L-1) (60:40, V/V) ...detailed

Solubility and mixing thermodynamics properties of Erythromycin ethylsuccinate (cas 1264-62-6) in different organic solvents08/09/2019

The solid-liquid equilibrium data of erythromycin ethylsuccinate in six pure organic solvents including tetrahydrofuran, acetone, acetonitrile, hexane, ethanol and 2-propanol were determined by using the gravimetric method over the temperature range from 288.15 K to 323.15 K. The experimental so...detailed