126400-41-7

Upstream product

• 121910-45-0 C₁₇H₂₀N₂OSi 
• 56176-56-8 E-1-pyrrolidino-1-butene 

Downstream Products

• 126400-43-9 5-ethyl-1,4-diphenyl-3,4-dihydropyrimidin-2(1H)-one 
• 126400-42-8 (4S,5R,6R)-5-Ethyl-6-hydroxy-1,4-diphenyl-tetrahydro-pyrimidin-2-one 

Relevant academic research and scientific papers

1,4-CYCLOADDITION OF 1,3-DIAZABUTADIENES WITH ENAMINES:AN EFFICIENT ROUTE TO THE PYRIMIDINE RING

Cycloaddition reactions of 2-trimethylsilyloxy- and 2-trimethylsilylthio-1,3-diazabutadienes with enamines leading to pyrimidone derivatives are described.

A SIMPLE APPROACH TO PYRIMIDINE AND QUINAZOLINE DERIVATIVES BY CYCLOADDITION OF 1,3-DIAZADIENES AND ENAMINES

The reaction of 2-trimethylsilyloxy- (1) and 2-trimethylsilylthio-1,3-diazabutadienes (2) with enamines derived from aliphatic aldehydes leads regio- and stereoselectively to substituted tetrahydropyrimidin-2(1H)-ones (3) and thiones (4) in high yields.Extension of this cycloaddition to cyclic enamines, e.g. derived from cyclohexanone, leading to quinazoline derivatives (9-10) is also described.These heterocycles undergo hydrolysis and dehydration to 3,4-dihydropyrimidine (7-8) and 3,4,5,6,7,8-hexahydroquinazoline (11-12) derivatives.