126403-78-9Relevant academic research and scientific papers
K-RAS G12C inhibitor as well as preparation method and application thereof
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Paragraph 0173; 0174; 0208-0211, (2021/08/14)
The invention relates to a K-RAS G12C inhibitor with a structure shown in a formula (I) as well as a preparation method and application of the K-RAS G12C inhibitor. A series of the compounds can be widely applied to preparation of drugs for treating tumors or cancers at least partially mediated by K-RAS G12C mutation, especially drugs for treating lung, liver and gall, gastrointestinal tract, blood system, skin, bone, urogenital tract, nervous system, gynecological and adrenal gland related malignant tumors or cancers, and are expected to be developed into a new generation of K-RAS G12C inhibitor drugs.
