126408-14-8

Basic information

• Product Name: methyl (2S,4R)-N-(allyloxycarbonyl)-4-hydroxypyrrolidine-2-carboxylate
• Synonyms: methyl (2S,4R)-N-(allyloxycarbonyl)-4-hydroxypyrrolidine-2-carboxylate
• CAS NO: 126408-14-8
• Molecular Weight: 229.233
• Mol File: 126408-14-8.mol
• Article Data: 4

Chemical Properties

• CAS DataBase Reference: methyl (2S,4R)-N-(allyloxycarbonyl)-4-hydroxypyrrolidine-2-carboxylate(CAS DataBase Reference)
• NIST Chemistry Reference: methyl (2S,4R)-N-(allyloxycarbonyl)-4-hydroxypyrrolidine-2-carboxylate(126408-14-8)
• EPA Substance Registry System: methyl (2S,4R)-N-(allyloxycarbonyl)-4-hydroxypyrrolidine-2-carboxylate(126408-14-8)

Safety Data

• Hazardous Substances Data: 126408-14-8(Hazardous Substances Data)

Upstream product

• 40216-83-9 L-4-hydroxyproline methyl ester hydrochloride 
• 2937-50-0 Allyl chloroformate 

Downstream Products

• 883991-68-2 (2S,4S)-2-{[(imino)(pyrazol-1-yl)methyl]carbamoyl}-4-tritylthio-1-(allyloxycarbonyl)pyrrolidine 
• 883991-82-0 (2S,4S)-2-{[(5,6-Dihydro-4H-pyrimidin-1-yl)-imino-methyl]-carbamoyl}-4-tritylsulfanyl-pyrrolidine-1-carboxylic acid allyl ester 
• 883991-83-1 (2S,4S)-2-[(Imino-pyrrolidin-1-yl-methyl)-carbamoyl]-4-tritylsulfanyl-pyrrolidine-1-carboxylic acid allyl ester 
• 883991-69-3 (2S,4S)-2-{[(imino)(thiomorpholin-4-yl)methyl]carbamoyl}-4-tritylthio-1-(allyloxycarbonyl)pyrrolidine 
• 883991-79-5 (2S,4S)-2-[(Imino-morpholin-4-yl-methyl)-carbamoyl]-4-tritylsulfanyl-pyrrolidine-1-carboxylic acid allyl ester 
• 883991-80-8 (2S,4S)-2-[(Imino-piperidin-1-yl-methyl)-carbamoyl]-4-tritylsulfanyl-pyrrolidine-1-carboxylic acid allyl ester 
• 883991-78-4 (2S,4S)-2-[(Imino-piperazin-1-yl-methyl)-carbamoyl]-4-tritylsulfanyl-pyrrolidine-1-carboxylic acid allyl ester 
• 883991-81-9 (2S,4S)-2-{[(4-Hydroxy-piperidin-1-yl)-imino-methyl]-carbamoyl}-4-tritylsulfanyl-pyrrolidine-1-carboxylic acid allyl ester 
• 883991-84-2 (2S,4S)-2-{[(2-Hydroxymethyl-pyrrolidin-1-yl)-imino-methyl]-carbamoyl}-4-tritylsulfanyl-pyrrolidine-1-carboxylic acid allyl ester 
• 625388-36-5 (2S,4S)-4-tritylthio-1-(allyloxycarbonyl)pyrrolidine-2-carboxylic acid methyl ester 
• 639457-00-4 (2S,4S)-4-tritylthio-1-(allyloxycarbonyl)pyrrolidine-2-carboxylic acid 
• 147505-57-5 (2S,4S)-N-allyloxycarbonyl-2-[(Z)-3-allyloxycarbonylamino-1-propenyl]-4-tritylthiopyrrolidine 
• 147505-61-1 (2S,4S)-N-allyloxycarbonyl-2-[(Z)-3-methanesulfonyloxy-1-propenyl]-4-tritylthiopyrrolidine 
• 147599-97-1 3-[(2S,4S)-N-allyloxycarbonyl-4-tritylthiopyrrolidin-2-yl]acrylic acid ethyl ester 

Relevant articles and documents

PROCESS FOR PRODUCTION OF CARBAPENEM DERIVATIVE AND CRYSTALLINE INTERMEDIATE THEREFOR

An object of the present invention is to provide a carbapenem synthetic intermediate which is advantageous in an industrial process. There are provided a process for producing Compound (I), or a pharmaceutically acceptable salt, or a solvate, or a crystal thereof, comprising reacting Compound (III) and Compound (IV) in the presence of the secondary amine, and a benzyl alcoholated crystal of Compound (I). There are further provided a method of deprotecting Compound (I) with a Pd catalyst, and a crystal of Compound (IV).

Synthesis and biological properties of new 1β-methylcarbapenems having tetrazolothioether moiety

The synthesis and biological activities of a series of new 1β-methylcarbapenems 1a-1 having tetrazolothioether moiety at C-5 position of pyrrolidine were described. Among these compounds, 1c showed the most potent antibacterial activity and advanced pharmacokinetics compared with imipenem and meropenem. (C) 2000 Elsevier Science Ltd. All rights reserved.