126410-76-2Relevant academic research and scientific papers
STEREOSELECTIVE SYNTHESIS OF THE HYDROXYETHYLENE ISOSTERE OF THE HIV PROTEASE (TYR-PRO) CLEAVAGE SITE
Thompson, Wayne J.,Ball, Richard G.,Darke, Paul L.,Zugay, Joan A.,Thies, J. E.
, p. 2957 - 2960 (2007/10/02)
The stereoselective syntheses and IC50's of Tyr-HE-Pro based inhibitors are reported.The -stereochemistry was preferred by HIV-1 protease.
New Approaches to the Synthesis of trans-Alkene Isosteres of Dipeptides
Spaltenstein, Andreas,Carpino, Philip A.,Miyake, Fumio,Hopkins, Paul B.
, p. 3759 - 3766 (2007/10/02)
Two new syntheses of protected dipeptide analogues bearing a trans carbon-carbon double bond in place of the amide linkage are reported.One route is a linear synthesis employing the rearrangement of an allylic selenide to a protected allylic amine.The second route is convergent and uses the Julia olefin synthesis in a key step.The latter route is fully stereocontrolled and has been used to prepare protected trans-alkene isosteres of the dipeptides TyrAla, PhePhe, LeuPhe, and LeuLeu.
