1264175-01-0Relevant academic research and scientific papers
Highly enantioselective mannich reactions with α-aryl silyl ketene acetals and imines
Notte, Gregory T.,Baxter Vu, Jenny M.,Leighton, James L.
, p. 816 - 818 (2011)
Mannich reactions with chiral silicon Lewis acid activated acylhydrazones and α-aryl silyl ketene acetals and α-aryl,α-alkyl silyl ketene imines proceed efficiently and with good to excellent levels of both diastereoselectivity and enantioselectivity. The reactions provide access to α-aryl,β-hydrazido esters and α-aryl,α-alkyl,β- hydrazido nitriles, which are valuable analogs of β-amino acids.
