126421-76-9Relevant academic research and scientific papers
Asymmetric syntheses with a new optically active perhydronaphthalene based chiral auxiliary
Hamon,Holman,Massy-Westropp
, p. 9593 - 9604 (2007/10/02)
(1R,4aS,8S,8aS)-8-(5'-Methoxy-2'-methylphenyl)-8-methyldecahydro-1-nap hthalenol 3a is a highly efficient chiral auxiliary in the Diels-Alder addition of its acrylate ester 5 and in the DIBAL-H and Grignard reactions of its phenylglyoxylate ester 7.
New chiral auxiliaries: Their use in the asymmetric hydrogenation of β-acetamidocrotonates
Potin,Dumas,d'Angelo
, p. 3483 - 3486 (2007/10/02)
Synthesis of chiral β-amido esters 7 with high diasteroisomeric excess was achieved by asymmetric hydrogenation (H2/PtO2) of stereogenic β-acetamidocrotonates 6 in which the chirality is present in the alkyl of the ester part. For such a purpose, new efficient chiral auxiliaries such as 2,2-diphenylcyclopentanol (12) and 1,1-diphenyl-3-methyl-2-butanol (13) were developed.
