126423-75-4Relevant academic research and scientific papers
Stereoselective total syntheses of the antitumor antibiotics (+)-actinobolin and (-)-bactobolin from a common bridged lactone intermediate
Garigipati,Tschaen,Weinreb
, p. 3475 - 3482 (2007/10/02)
Efficient, highly steroselective approaches have been developed to (+)-actinobolin (1) and (-)-bactobolin (3) from bridged α-keto lactone 11, which can be readily prepared via intramolecular SnCl4 catalyzed ene reaction of cyclohexenol glyoxyla
Stereoselective Total Synthesis of the Antitumor Antibiotic (-)-Bactobolin
Garigipati, Ravi S.,Weinreb, Steven M.
, p. 4143 - 4145 (2007/10/02)
The first total synthesis of the biologically active microbial metabolite bactobolin (2) has been achieved.An efficient, stereoselective route to 2 in 16 steps from previously prepared α-keto lactone 3 is outlined.
