126434-73-9 Usage
Derivative of indole
Heterocyclic aromatic organic compound The compound is based on the indole structure, which is an aromatic organic compound containing a heterocyclic ring (a ring containing at least one non-carbon atom).
Methylated form
5,6-dihydroxyindole-2-carboxylic acid 1H-Indole-2-carboxylicacid,5,6-dihydroxy-1-methyl-(9CI) is a modified version of 5,6-dihydroxyindole-2-carboxylic acid, with an additional methyl group (CH3) attached.
Importance in melanin biosynthesis
Key intermediate 1H-Indole-2-carboxylicacid,5,6-dihydroxy-1-methyl-(9CI) plays a crucial role in the production of melanin, a pigment responsible for the color of skin, hair, and eyes.
Potential substrate for enzymes
Involved in tryptophan degradation 1H-Indole-2-carboxylicacid,5,6-dihydroxy-1-methyl-(9CI) may be acted upon by enzymes that break down tryptophan, an essential amino acid important for various biological processes.
Pharmaceutical and biological activities
Studied for potential applications Researchers have investigated the possible uses of 1H-Indole-2-carboxylicacid,5,6-dihydroxy-1-methyl-(9CI) in medicine and biology, particularly in relation to melanin synthesis and tryptophan metabolism pathways.
Check Digit Verification of cas no
The CAS Registry Mumber 126434-73-9 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 1,2,6,4,3 and 4 respectively; the second part has 2 digits, 7 and 3 respectively.
Calculate Digit Verification of CAS Registry Number 126434-73:
(8*1)+(7*2)+(6*6)+(5*4)+(4*3)+(3*4)+(2*7)+(1*3)=119
119 % 10 = 9
So 126434-73-9 is a valid CAS Registry Number.
126434-73-9Relevant academic research and scientific papers
GPR35 LIGANDS AND THE USES THEREOF
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Paragraph 0389; 393; 0399, (2013/03/26)
Disclosed are compositions and methods for reducing the risk of and/or treatment of diseases which are pathophysiologically related to GPR35, and/or GPR35-hERG signaling complex. For example, disclosed are compounds for reducing the risk of and/or treatin
Synthesis and agonistic activity at the GPR35 of 5,6-dihydroxyindole-2- carboxylic acid analogues
Deng, Huayun,Fang, Ye
, p. 550 - 554 (2012/09/05)
5,6-Dihydroxyindole-2-carboxylic acid (DHICA), an intermediate of melanin synthesis and an eumelanin building block, was recently discovered to be a GPR35 agonist with moderate potency. Here, we report the synthesis and pharmacological characterization of a series of DHICA analogues against GPR35 using both label-free dynamic mass redistribution and Tango β-arrestin translocation assays. This led to identification of novel GPR35 agonists with improved potency and/or having biased agonism.
