126443-35-4

Basic information

• Product Name: Benzonitrile, 4-[(1E)-3-(4-chlorophenyl)-3-oxo-1-propenyl]-
• CAS NO: 126443-35-4
• Molecular Formula: C16H10ClNO
• Molecular Weight: 267.714
• Mol File: 126443-35-4.mol
• Article Data: 2

Chemical Properties

• CAS DataBase Reference: Benzonitrile, 4-[(1E)-3-(4-chlorophenyl)-3-oxo-1-propenyl]-(CAS DataBase Reference)
• NIST Chemistry Reference: Benzonitrile, 4-[(1E)-3-(4-chlorophenyl)-3-oxo-1-propenyl]-(126443-35-4)
• EPA Substance Registry System: Benzonitrile, 4-[(1E)-3-(4-chlorophenyl)-3-oxo-1-propenyl]-(126443-35-4)

Safety Data

• Hazardous Substances Data: 126443-35-4(Hazardous Substances Data)

Upstream product

• 99-91-2 para-chloroacetophenone 
• 105-07-7 4-cyanobenzaldehyde 

Downstream Products

• 101081-33-8 4-[1,2-dibromo-3-(4-chloro-phenyl)-3-oxo-propyl]-benzonitrile 

Relevant articles and documents

Antifungal activity of chalcones: A mechanistic study using various yeast strains

We reported the synthesis, antifungal evaluation and study on substituent effects of 21 chalcones. A lot of genetically defined strains belonging to different yeast genera and species, namely Saccharomyces cerevisiae, Hansenula polymorpha and Kluyveromyces lactis, were used as test organisms. Concerning the mode of the antifungal action of chalcones it was shown that DNA was probably not the main target for the chalcones. It was revealed that the yeast's intracellular glutathione and cysteine molecules play significant role as defence barrier against the chalcone action. It was also shown that chalcones may react with some proteins involved in cell separation.