1264526-34-2Relevant academic research and scientific papers
Copper-catalyzed one-pot synthesis of 2-thioxo-2,3-dihydroquinazolin-4(1H)- ones from ortho-bromobenzamides and isothiocyanates
Wang, Fei,Zhao, Peng,Xi, Chanjuan
supporting information; experimental part, p. 231 - 235 (2011/02/28)
Copper-catalyzed tandem reaction of ortho-bromobenzamides and isothiocyanates is described, which provides an efficient and practical route for the synthesis of 2-thioxo-2,3-dihydroquinazolin-4(1H)-ones. The optimal condition involved the following parameters: CuI as precatalyst, Cs 2CO3 as base, N,N′-dimethylethane-1,2-diamine as ligand, and toluene as solvent, with reaction temperature at 120 °C.
