126453-97-2

Upstream product

• 126359-50-0 6(R)-<2-<6(R)-<1(S)-<(2,2-dimethylbutyryl)oxy>-3(R)-methyl-4-<(o-nitrophenyl)seleno>butyl>-2(S)-methyl-5(R)-hydroxycyclohexyl-1(S)>ethyl>-4(R)-hydroxy-3,4,5,6-tetrahydro-2H-pyran-2-one 
• 126359-51-1 6(R)-<2-<6(R)-<1(S)-<(2,2-dimethylbutyryl)oxy>-3-methyl-3-butenyl>-2(S)-methyl-5(R)-hydroxycyclohexyl-1(S)>ethyl>-4(R)-hydroxy-3,4,5,6-tetrahydro-2H-pyran-2-one 
• 126359-47-5 6(R)-<2-<6(R)-<1(S)-<(2,2-dimethylbutyryl)oxy>-4-hydroxy-3(R)-methylbutyl>-2(S)-methyl-5(R)-hydroxycyclohexyl-1(S)>ethyl>-4(R)-hydroxy-3,4,5,6-tetrahydro-2H-pyran-2-one 
• 126359-49-7 6(R)-<2-<6(R)-<1(S)-<(2,2-dimethylbutyryl)oxy>-3(R)-methyl-4-iodobutyl>-2(S)-methyl-5(R)-hydroxycyclohexyl-1(S)>ethyl>-4(R)-hydroxy-3,4,5,6-tetrahydro-2H-pyran-2-one 
• 126359-52-2 6(R)-<2-<8(S)-<(2,2-dimethylbutyryl)oxy>-2(S),6-dimethyl-5-oxa-6-(iodomethyl)-1,2,3,4,4a(R),7,8,8a(R)-octahydronaphthyl-1(S)>ethyl>-4(R)-hydroxy-3,4,5,6-tetrahydro-2H-pyran-2-one 
• 108-98-5 thiophenol 

Relevant academic research and scientific papers

3-Hydroxy-3-methylglutaryl-coenzyme A Reductase Inhibitors. 7. Modification of the Hexahydronaphthalene Moiety of Simvastanin: 5-Oxygenated and 5-Oxa Derivatives

Modification of the hexahydronaphthalene ring 5-position in simvastatin 2a via oxygenation and oxa replacement afforded two series of derivatives which were evaluated in vitro for inhibition of 3-hydroxy-3-methylglutaryl-coenzyme.A reductase and acutely i