1264675-76-4Relevant academic research and scientific papers
Highly enantioselective addition of diethylzinc to aldehydes catalyzed by novel chiral tert-amino alcohols
Zhang, Cong-Hai,Yan, Sheng-Jiao,Pan, Sheng-Qiang,Huang, Rong,Lin, Jun
experimental part, p. 869 - 873 (2010/10/04)
A series of novel chiral tert-amino alcohols 4a-h derived from enantiomerically pure phenylalanine were synthesized efficiently and used as chiral ligands in the catalytic enantioselective ethylation of aldehydes with diethylzinc (diethylzinc-to-aldehyde addition). The use of 10 mol % of the amino alcohols led to the corresponding sec-alcohols with excellent enantioselectivities (up to 100% ee) and high yields.
