126474-01-9

Upstream product

• 28217-95-0 2-benzylpyrazine 

Downstream Products

• 126474-10-0 2-[Phenyl-(4-trimethylsilanyl-but-3-ynyloxy)-methyl]-pyrazine 
• 126474-16-6 8-Phenyl-4-trimethylsilanyl-5,8-dihydro-6H-pyrano[3,4-b]pyridine 
• 126474-17-7 1-Phenyl-5-trimethylsilanyl-3,4-dihydro-1H-pyrano[3,4-c]pyridine 
• 126474-03-1 1-Phenyl-3,4-dihydro-1H-pyrano[3,4-c]pyridine 
• 126474-02-0 8-Phenyl-5,8-dihydro-6H-pyrano[3,4-b]pyridine 
• 126473-95-8 α-phenyl-α-(3-butynyloxy)methylpyrazine 

Relevant academic research and scientific papers

PYRIMIDINONE DERIVATIVES AND METHODS OF USE THEREOF

The present invention relates to Pyrimidinone Derivatives, compositions comprising a Pyrimidinone Derivative, and methods of using the Pyrimidinone Derivatives for treating or preventing obesity, diabetes, a metabolic disorder, a cardiovascular disease or a disorder related to the activity of G protein-coupled receptor 119 ("GPR119") in a patient.

INTRAMOLECULAR INVERSE ELECTRON DEMAND DIELS-ALDER REACTIONS OF PYRAZINES

Thermally induced intramolecular Diels-Alder cyclisations of (alkynyloxyalkyl)pyrazines to dihydropyranopyridines have been studied in the solvent undecane.The introduction of a phenyl group in the α-position of the 3-butynyloxymethyl side chain leads to a 3-4 fold increase of the reaction rate, while the influence of a γ-phenyl group on the rate is negligible.The (3-butynyloxymethyl)pyrazine reacts about 7 times slower than the (3-propynyloxyethyl)pyrazine; the presence of a trimethylsilyl group at the terminus of the alkyne decreases in general the rate of the intramolecular cyclisation.The mechanisms are discussed.