126480-73-7Relevant academic research and scientific papers
A new synthetic route to macrocycles: Synthesis of large ring enaminolactones
Jourdain,Pommelet
, p. 1545 - 1548 (2007/10/02)
Macrocyclic enaminolactones 5 are prepared in three steps from commercially available chloroalcohols 1. The cyclization step is performed by intramolecular nucleophilic addition of the hydroxy group to an aminomethyleneketene generated by thermolysis.
Synthese d'oxazepine-1,4 ones-7 par thermolyse de β-hydroxyalkylaminomethylenemalonates d'isopropylidene
Grandjean, Didier,Dhimane, Hamid,Pommelet, Jean-Claude,Chuche, Josselin
, p. 657 - 660 (2007/10/02)
β-hydroxyalkylaminomethylene Meldrum's acid derivatives 1a-d lead by gas-phase thermolysis, to monocyclic oxazepinones 7; in the contrary, 1e affords quinolone 8e.The formation of compound 7 can be rationalized by addition of the hydroxy group on the amin
