126486-33-7Relevant academic research and scientific papers
Aminolysis of 2,2-difluoro-4-alkoxy-1,3,2-dioxaborinanes: route to β-keto amides and β-enamino carboxamides
?tefane, Bogdan,Polanc, Slovenko
, p. 10902 - 10913 (2007)
4-Alkoxy substituted 1,3,2-dioxaborinanes 1, readily available from β-keto esters, undergo substitution reactions under mild reaction conditions with primary and secondary amines, deriving the 4-alkylamino analogue 2. Reactions of 1 with substituted phenylhydrazines gave the corresponding hydrazones, or pyrazolones, and 5-alkoxy-1H-pyrazoles as a mixture of products.
A new regio- and chemoselective approach to β-keto amides and β-enamino carboxamides via 1,3,2-dioxaborinanes
?tefane, Bogdan,Polanc, Slovenko
, p. 698 - 702 (2007/10/03)
Surprisingly, 5,6-disubstituted 2,2-difluoro-4-alkoxy-1,3,2-dioxaborinanes, which can be easily obtained from β-keto esters, reacted regio- and chemoselectively with amines under mild reaction conditions to form 2,2-difluoro-4-alkylamino-1,3,2-dioxaborina
Short and efficient access to β-ketoamides
Cossy, Janine,Belotti, Damien,Bouzide, Abderahim,Thellend, Annie
, p. 723 - 729 (2007/10/02)
β-Ketoamides are obtained in good yields either through a photochemical rearrangement of diazodiketones or by aminolysis of β-ketoesters. photolysis / Wolff rearrangement / ketoketene / β-ketoesters / aminolysis /4-(dimethylamino)pyridine / β-ketoamides
A 4-Dimethylaminopyridine-Catalyzed Aminolysis of β-Ketoesters. Formation of β-Ketoamides
Cossy, Janine,Thellend, Annie
, p. 753 - 755 (2007/10/02)
Alkyl 3-oxoalkanoates (β-ketoesters) react with amines in the presence of a catalytic amount of 4-dimethylaminopyridine (DMAP) under mild conditions to form 3-oxoalkanamides (β-ketoamides) in good yields.
