126503-24-0Relevant academic research and scientific papers
Stereoselective nucleophilic addition reactions to cyclic n-acyliminium ions using the indirect cation pool method: Elucidation of stereoselectivity by spectroscopic conformational analysis and dft calculations
Mitsudo, Koichi,Yamamoto, Junya,Akagi, Tomoya,Yamashita, Atsuhiro,Haisa, Masahiro,Yoshioka, Kazuki,Mandai, Hiroki,Ueoka, Koji,Hempel, Christian,Yoshida, Jun-ichi,Suga, Seiji
, p. 1192 - 1202 (2018)
In this study, six-membered N-acyliminium ions were generated by the “indirect cation pool” method and reacted with several nucleophiles. These reactions afforded disubstituted piperidine derivatives with high diastereoselectivities and good to excellent
α-Lithioamine Synthetic Equivalents: Syntheses of Diastereoisomers from the Boc Piperidines
Beak, Peter,Lee, Won Koo
, p. 2578 - 2580 (2007/10/02)
The α'-lithiations and electrophilic substitutions of selected Boc piperidines provide single or separable diastereoisomeric 2-substituted, 2,4-disubstituted, and 2,4,6-trisubstituted Boc piperidines which are readily hydrolyzed to the substituted piperidines.
