1265146-03-9Relevant articles and documents
Pyrrole-based scaffolds for turn mimics
Ko, Eunhwa,Burgess, Kevin
, p. 980 - 983 (2011/04/22)
Two amino acid derived synthons were combined to give homopropargylic amines 2. Platinum dichloride was used to cyclize these intermediates into pyrroles 3 which collapsed to the target secondary structure mimics 1 on treatment with base. Side chains of these compounds overlay with an idealized type 1 β-turn and with an inverse γ-turn.(Figure Presented)