126517-27-9Relevant academic research and scientific papers
POTENTIAL NOOTROPIC AGENTS: SYNTHESIS OF SOME 1,4-DISUBSTITUTED 2-OXOPYRROLIDINES AND SOME RELATED COMPOUNDS
Valenta, Vladimir,Urban, Jiri,Taimr, Jan,Polivka, Zdenek
, p. 1126 - 1136 (2007/10/02)
4-(Aminomethyl)-1-benzyl-2-oxopyrrolidine (VI) was transformed by treatment with (4-benzhydrylpiperazin-1-yl)carbonyl chlorides IIIb-IIId and with (4-methylpiperazin-1-yl)carbonyl chloride (IIIa) to the carboxamides IVa-IVd.Heating of 1-(ethoxycarbonylmethyl)-2,4-dioxopyrrolodine (XIX) in acetonitrile in the presence of water afforded XVIIIa.Treatment with ammonia led to the diamide XVIIIc, while alkaline hydrolysis of XVIIIa gave the dicarboxylic acid XVIIIb. 4-(Aminomethyl)-1-(4-methylthiobenzyl)-2-oxopyrrolidine (XII) was prepared by the reaction of 4-(methylthio)benzylamine with itaconic acid and the following sequence of reaction ...
POTENTIAL ANTICONVULSANTS: 3-CHLOROBENZOPHENONE DERIVATIVES
Jilek, Jiri,Urban, Jiri,Kmonicek, Vojtech,Pomykacek, Josef,Holubek, Jiri,et al.
, p. 2248 - 2260 (2007/10/02)
Reactions of 2-(2-iodoacetamido)-5-chlorobenzophenone with 2-amino-2-phenylethanol, 2-amino-1-phenylethanol, 3-amino-2-phenylpropanol, D(+)-norpseudoephedrine, and 2-aminopropane-2-carbonitrile gave the 2-substituted N-(2-benzoyl-4-chlorophenyl)acetamides X-XIV. 2,3'-Dichlorobenzhydrol (XVI) and 2,3'-dichlorobenzhydryl chloride (XIX) were transformed to the ethers XVII and XVIII and to the amines XXI-XXIV.Compound XVI was oxidized to the ketone XXV which was transformed via the oxime XXVI to compound XXVII.The basic products were converted to salts which were pharmacologically tested.Compounds X, XVII, XXIII, and XXVII showed anticonvulsant effects and some other neurotropic activities.
