126519-75-3Relevant academic research and scientific papers
Disubstituted tetrahydrofurans and dioxolanes as PAF antagonists
Bartroli,Carceller,Merlos,Garcia-Rafanell,Forn
, p. 373 - 386 (2007/10/02)
A new series of disubstituted tetrahydrofuran and dioxolane derivatives were prepared and evaluated for their PAF antagonist activity in the PAF-induced in vitro platelet-aggregation and in vivo hypotension tests. Several of these compounds exhibited more potent activity than the structurally related 2-[N-acetyl-N-[[[[2-methoxy-3-[(octadecylcarbamoyl)oxy]propoxy] carbonyl]amino]methyl]-1-ethylpyridinium chloride (CV-6209, 3) in the in vitro assay, whereas all showed less potency in the in vivo test. The role of both the substituent nature and the placement and number of oxygen atoms in the ring are discussed. A qualitative SAR study was carried out on these nuclei.
2,4-disubstituted 1,3-dioxolanes and pharmaceutical use
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, (2008/06/13)
The present invention describes novel 2,4-disubstituted 1,3-dioxolanes having the formula I STR1 wherein R1 represents a long chain alkyl group; X is a covalent single bond, a carbonyl group, a carboxyl group, a carbamoyl group or a --O--P(=O)(
