126521-63-9Relevant academic research and scientific papers
Cobalt-Catalyzed Silylcarbonylation of Unactivated Secondary Alkyl Tosylates at Low Pressure
Roque Pena, Joan E.,Alexanian, Erik J.
, p. 4413 - 4415 (2017/09/11)
A catalytic preparation of silyl enol ethers from unactivated secondary alkyl tosylates is reported. An inexpensive cobalt catalyst is used under mild conditions with low pressures of carbon monoxide. Nucleophilic, anionic cobalt carbonyls facilitate the catalytic activation of a range of alkyl tosylates. The silylcarbonylation offers a practical approach to synthetically valuable silyl enol ethers from simple starting materials.
Copper-catalyzed cross-coupling of nonactivated secondary alkyl halides and tosylates with secondary alkyl grignard reagents
Yang, Chu-Ting,Zhang, Zhen-Qi,Liang, Jun,Liu, Jing-Hui,Lu, Xiao-Yu,Chen, Huan-Huan,Liu, Lei
supporting information; experimental part, p. 11124 - 11127 (2012/08/28)
Practical catalytic cross-coupling of secondary alkyl electrophiles with secondary alkyl nucleophiles under Cu catalysis has been realized. The use of TMEDA and LiOMe is critical for the success of the reaction. This cross-coupling reaction occurs via an SN2 mechanism with inversion of configuration and therefore provides a general approach for the stereocontrolled formation of C-C bonds between two tertiary carbons from chiral secondary alcohols.
