1265312-61-5 Usage
General Description
(4'-(trifluoromethyl)-[1,1'-biphenyl]-2-yl)boronic acid is a chemical compound with the molecular formula C12H10BF3O2. It is commonly used as a reagent in organic synthesis and pharmaceutical research. The boronic acid functional group allows it to participate in a variety of reactions, including Suzuki-Miyaura coupling, which is widely used in the construction of carbon-carbon bonds. The presence of the trifluoromethyl and biphenyl groups also imparts specific steric and electronic properties to the molecule, making it useful for fine-tuning chemical reactions and promoting selectivity. Furthermore, the compound's boronic acid moiety makes it a potential candidate for the development of pharmaceuticals, as it can be used to target specific biological processes or enzymes. Overall, (4'-(trifluoromethyl)-[1,1'-biphenyl]-2-yl)boronic acid is a versatile and valuable chemical reagent with numerous applications in organic chemistry and drug discovery.
Check Digit Verification of cas no
The CAS Registry Mumber 1265312-61-5 includes 10 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 7 digits, 1,2,6,5,3,1 and 2 respectively; the second part has 2 digits, 6 and 1 respectively.
Calculate Digit Verification of CAS Registry Number 1265312-61:
(9*1)+(8*2)+(7*6)+(6*5)+(5*3)+(4*1)+(3*2)+(2*6)+(1*1)=135
135 % 10 = 5
So 1265312-61-5 is a valid CAS Registry Number.
1265312-61-5Relevant articles and documents
Rh(III)-Catalyzed C-H Activation of Boronic Acid with Aryl Azide
Xu, Shiyang,Huang, Baoliang,Qiao, Guanyu,Huang, Ziyue,Zhang, Zhen,Li, Zongyang,Wang, Peng,Zhang, Zhenhua
supporting information, p. 5578 - 5582 (2018/09/25)
A Rh(III)-catalyzed C-H activation of boronic acid with aryl azide to obtain unsymmetric carbazoles, 1H-indoles, or indolines has been developed. The reaction constructs dual distinct C-N bonds via sp2/sp3 C-H activation and rhodium nitrene insertion. Synthetically, this approach represents an access to widely used carbazole derivatives. The practical application to CBP and unsymmetric TCTA derivatives has also been performed. Mechanistic experiments and DFT calculations demonstrate that a five-membered rhodacycle species is the key intermediate.
