126545-09-3

Upstream product

• 112403-88-0 O-methyl N-phenyl-3-phenylpropanohydroxamate 
• 63677-96-3 (E)-2-hydroxy-2-methyl-5-phenylpent-4-en-3-one 
• 90-04-0 2-methoxy-phenylamine 
• 501-52-0 3-Phenylpropionic acid 
• 645-45-4 hydrocinnamic acid chloride 

Relevant academic research and scientific papers

Silica gel-mediated amide bond formation: An environmentally benign method for liquid-phase synthesis and cytotoxic activities of amides

An efficient, functional group tolerable, and environmentally benign process for the synthesis of amides was developed. No activation reagents or scavengers are required in this process. Purification of desired compounds is easy, rapid, and cost-effective. This protocol provides an alternative for the combinatorial liquid-phase synthesis of amide libraries for drug discovery. By this method, a number of amides were prepared and evaluated in vitro against a panel of human tumor cell lines. Cinnamic amide IV-4 was found to be the most potent compound synthesized against four human tumor cell lines.

Catalytic amide formation with α′-hydroxyenones as acylating reagents

α′-Hydroxyenones undergo clean, catalytic amidations with amines promoted by the combination of an N-heterocyclic carbene and 1,2,4-triazole. The Royal Society of Chemistry 2009.

NITROGEN-CONTAINING HETEROARYL COMPOUNDS HAVING HIV INTEGRASE INHIBITORY ACTIVITY

A compound of the formula (I): wherein Z4, Z5 and Z9 each is independently carbon atom or nitrogen atom; Y is hydroxy, mercapto or amino; RA is a group of the formula: (wherein C ring is nitrogen-containing heteroaryl) has an inhibitory activity against integrase.

AlCl3-mediated Regioselective Migration of a Methoxy Group of N-Methoxy-N-phenylamides to the ortho Position of the Phenyl Ring

AlCl3-mediated decomposition of N-methoxy-N-phenylamides in dichloroethane leads to regioselective intramolecular migration of the methoxy group from the nitrogen to the ortho position of the phenyl ring via a tight ion pair intermediate.